Rapid Changes in Serum Testosterone in Men With Newly Diagnosed Type 2 Diabetes With Intensive Insulin and Metformin
نویسندگان
چکیده
OBJECTIVE To investigate the effect of metformin on testosterone levels in men with type 2 diabetes mellitus (T2DM). RESEARCH DESIGN AND METHODS Seventy newly diagnosed drug-naive T2DM and HbA1c >9.0% (75 mmol/mol) were treated intensive insulin pump therapy for 5 days to achieve glucose normalization. They randomized control (continued only) (plus metformin) groups (1:1) 1 month. Testosterone was measured at baseline, randomization, after 1-month treatment. RESULTS Total, free, bioavailable increased significantly within (all P < 0.001). After month, compared group, group had lower total (12.7 vs. 15.3 nmol/L), free (0.20 0.24 (4.56 5.31 nmol/L) 0.05). CONCLUSIONS In T2DM, oral may decrease serum independent blood control. The effects long-term need further study.
منابع مشابه
Intensive insulin therapy in newly diagnosed type 2 diabetes.
The natural history of type 2 diabetes is characterised by worsening hyperglycaemia and progressive deterioration in function of the insulin-secreting pancreatic β cells. Despite intense investigative eff orts, the pathophysiological basis underlying β-cell dysfunction (and the concomitant loss of β-cell mass) remains unclear. Nevertheless, the central importance of declining β-cell function in...
متن کاملThe Evaluation of Serum Level of Testosterone and Sex Hormone- Binding Globulin in Men with Type 2 Diabetes
OBJECTIVE: To evaluate the relationship between serum level of testosterone and sex hormone-binding globulin in men with type 2 diabetes. MATERIALS AND METHODS: In this case-control study, forty men aged 40-70 with type 2 diabetes mellitus were randomly selected and compared with 40 non-diabetic men. The two groups were matched for their age and BMI. After complete observation and examination...
متن کاملSitagliptin/Metformin Versus Insulin Glargine Combined With Metformin in Obese Subjects With Newly Diagnosed Type 2 Diabetes
To compare the therapeutic effects of different regimens in Chinese obese type 2 diabetic mellitus (T2DM) patients. From October 2013 to July 2014, a total of 166 T2DM outpatients who attended the Shanghai Changhai Hospital and the Yijishan Hospital of Wannan Medical College were randomly assigned into an experimental sitagliptin/metformin combined with low caloric diet group (n = 115) and an i...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Diabetes Care
سال: 2021
ISSN: ['1935-5548', '0149-5992']
DOI: https://doi.org/10.2337/dc20-1558